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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Lucknow
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On Aug 2018




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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


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Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
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Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Original article / research
Year : 2023 | Month : November | Volume : 17 | Issue : 11 | Page : ZC21 - ZC24 Full Version

Comparison of Shear Bond Strength and Adhesive Remnant Score of Orthodontic Brackets Bonded with Three Different Orthodontic Adhesives: An In-vitro Study


Published: November 1, 2023 | DOI: https://doi.org/10.7860/JCDR/2023/65619.18723
Kavitha Ramsundar, Ravindra Kumar Jain

1. Resident, Department of Orthodontics, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India. 2. Professor, Department of Orthodontics, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India.

Correspondence Address :
Dr. Ravindra Kumar Jain,
Professor, Department of Orthodontics, Saveetha Dental College and Hospital, 162, Poonamallee High Road, Velappan Chavadi, Chennai-600096, Tamil Nadu, India.
E-mail: ravindrakumar@saveetha.com

Abstract

Introduction: Adequate bond strength between orthodontic brackets and enamel is necessary to withstand masticatory forces. Priming involves applying a primer before using the adhesive as a separate step. To reduce bonding time, manufacturers have introduced self-priming adhesives.

Aim: To evaluate the Shear Bond Strength (SBS) and Adhesive Remnant Index (ARI) scores of a Bis-GMA based self-priming adhesive (Orthofix SPA, Anabond) and compare it with a 2-Hydroxyethyl Methacrylate (HEMA) based self-priming adhesive (Aqualine LC, Tomy ortho) and a Bis-GMA containing primer-based orthodontic adhesive (Transbond XT, 3M).

Materials and Methods: The present In-vitro study was conducted at the White Lab., Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India, from December 2020 to January 2021. A total 54 freshly extracted premolar teeth were collected and divided into three groups (Group A - Orthofix SPA, Group B - Transbond XT, and Group C - Aqualine LC) based on the adhesive used. A 0.022 metal orthodontic brackets were bonded, and SBS and ARI scores of the samples were assessed. The Shapiro-Wilk test for normality was conducted. One-way Analysis of Variance (ANOVA) was used to compare the mean and standard deviation of SBS values and ARI scores among the three groups, and a post-hoc Tukey test was performed for inter group comparisons.

Results: Significant inter group differences were observed (p=0.004). Group A had lower SBS than Groups B and C. Significant inter group differences (p-value of 0.003) in ARI scores were noted, with Group A having the lowest scores.

Conclusion: The Bis-GMA self-priming adhesive (Orthofix SPA) exhibited lower SBS and ARI scores compared to commercially available HEMA-based self-priming adhesive systems and primer-based Bis-GMA adhesive systems.

Keywords

Bonding, Composite, Primerless, Self priming adhesive

Bonding of orthodontic attachments to tooth enamel is a crucial step in orthodontic treatment, facilitated by using adhesives after etching the enamel surfaces (1). Priming the etched enamel surface moisturises and protects it from demineralisation caused by bacterial actions (2). Although priming is beneficial, omitting it can reduce the time required for placing attachments (3). SBS refers to the maximum force an adhesive joint can withstand without fracturing (4). Clinical bonding has been found to be successful with an SBS of 6-8 MPa (5),(6). Bracket bond failures can occur immediately after placement when subjected to occlusal loading (7). Adhesive contraction during bonding or routine oral functions like mastication can lead to bond failures (8). Numerous studies on the bond failure rates of various adhesive systems have already been published (9),(10),(11),(12).

Orthofix SPA is a recently introduced single-component light-cure paste system designed for bonding both metal and ceramic orthodontic brackets to enamel. It is a Bis-GMA based self-priming adhesive, and since it does not require a separate priming step, it reduces chair-side time for operators (13). There are currently no studies comparing this self-priming adhesive with other adhesives. Therefore, the purpose of present study was to assess the SBS and ARI scores of a Bis-GMA based self-priming adhesive (Orthofix SPA, Anabond) and compare it with a commercially available HEMA-based self-priming adhesive (Aqualine LC, Tomy ortho) and a Bis-GMA-based primer orthodontic adhesive (Transbond XT, 3M).

Material and Methods

The present In-vitro study was conducted at the White Lab, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India, from December 2020 to January 2021. The study was approved by the scientific review board of the institution (IRB number: SRB/SDC/ORTHO-2007/22/014).

Study Procedure

Total 54 freshly extracted healthy premolar teeth, without caries, restorations, or developmental anomalies, were collected and used for the study. The sample size for the current investigation was determined based on a prior study (14). With a significance level of 0.05 and a power of 95%, a final sample of 54 teeth was obtained.

The extracted premolars were soaked in hydrogen peroxide for 24 hours. After 24 hours, the samples were cleaned with distilled water and stored in saline. Eighteen samples were assigned to each group: Group A - Orthofix SPA, Group B - Transbond XT, and Group C - Aqualine LC light-cure adhesive systems. Metal premolar brackets (0.022*0.028 inches, 3M Unitek Gemini) were bonded to the facial surfaces after pumice polishing and etching with 37% phosphoric acid thixotropic etching gel (Axotech), following the manufacturer’s recommendations. Subsequently, all samples were individually mounted in acrylic resin blocks, with only the coronal part visible (Table/Fig 1). SBS was assessed using an Instron Universal testing equipment (Instron E3000 UTM, Norwood, MA, USA). The equipment was equipped with a flattened steel rod for applying occlusal-gingival pressure to the bonded brackets, resulting in a shear force at the bracket-tooth interface. The measurements were recorded in Megapascals (MPa) (15).

After debonding the mounted teeth with brackets, the coronal portion was sectioned. The ARI scores were evaluated according to Artün and Bergland’s method, which involved quantifying the amount of adhesive residue left on each tooth enamel surface using a Scanning Electron Microscope (JSM-IT800 NANO SEM) (Table/Fig 2),(Table/Fig 3),(Table/Fig 4) (16).

Statistical Analysis

Based on the data analysis, a chart was constructed, and statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) (Version 26 Inc., Chicago, IL, USA). The Shapiro-Wilk test was conducted to assess normality. The mean and Standard Deviation (SD) of the SBS values and ARI scores of the three groups were compared using one-way ANOVA. The post-hoc Tukey test was performed to compare between the groups. p-values below 0.05 were considered significant.

Results

The Shapiro-Wilk test and P-P plot, as well as numerical and graphical normality tests, indicated that the dependent variables were normally distributed.

SBS: The mean and SD of SBS in Group A, Group B, and Group C were 0.81±0.5 MPa, 8.55±4.1 MPa, and 9.08±6.5 MPa, respectively. There was a statistically significant difference observed between the groups (p=0.004) (Table/Fig 3),(Table/Fig 5). Significant differences were noted between groups in the post-hoc comparisons, except between Group B and Group C (Table/Fig 6). Group A exhibited the lowest SBS.

ARI scores: The mean ARI scores for all the groups are presented in (Table/Fig 5). The inter group difference was statistically significant (p-value=0.003). In the post-hoc comparisons, significant differences were noted between groups, except between Group B and Group C (Table/Fig 6).

Discussion

Bond failures in orthodontic practice increase treatment duration and costs, leading to the introduction of various adhesive systems. SBS and ARI scores are measured outcomes in the present study. SBS refers to the maximum force an adhesive joint can withstand before fracturing. Sufficient SBS is necessary to prevent undesirable bracket failures, which can affect overall treatment outcomes (4). Bracket bond failures are directly related to the SBS of the adhesive used, and other factors such as bonding procedures, tooth surface and morphology, occlusal interferences, patient dietary habits, masticatory load, and treatment duration also influence bond failures (17),(18). Frequent bracket failures result in increased costs and treatment duration.

The current study aimed to assess the SBS and ARI scores of a Bis-GMA based self-priming adhesive (Orthofix SPA) and compare them with commercially available HEMA-based self-priming and Bis-GMA-based primer adhesive systems (Aqualine LC, Transbond XT). It was observed that the SBS of the Bis-GMA based self-priming adhesive was significantly lower than that of the Bis-GMA based primer adhesive and the HEMA-based self-priming adhesive. The bond strength of the novel primerless adhesive (Orthofix SPA) was lower than the recommended SBS (6-8 MPa) for successful clinical bonding (7). ARI scores were significantly lower for the Bis-GMA based self-priming adhesive compared to the other adhesives.

In the current study, a comparison of the SBS was conducted between the Bis-GMA based self-priming adhesive and both a primer-based adhesive and a HEMA-based self-priming adhesive system. The results showed that the HEMA-based self-priming adhesive (Aqualine LC) exhibited the highest SBS. The lower SBS of the Bis-GMA based self-priming adhesive could be attributed to compositional differences and flow properties. Previous In-vitro studies have investigated the SBS of primerless adhesives and compared them with primer-based adhesives, consistently reporting lower SBS for primerless adhesives (19),(20). The findings of the current study align with these previous studies, with the only difference being the brands of adhesives used. In-vivo studies have also been conducted in the past, comparing clinical bond failures while using primerless adhesives for orthodontic bonding (10),(21). In a clinical study by Rai AK, a higher bond failure rate was reported when Transbond XT was used without a primer compared to using the primer along with the Bis-GMA based primer adhesive (Transbond XT) (21).

Samantha C et al., attempted to compare the clinical bond failures between two conventional primer-based adhesives (Orthofix, Transbond XT), but no literature on self-priming adhesives from the same company has been reported (22). Vaheed NA et al., reported that lower ARI scores were associated with a higher chance of bond failures (23). In the current study, it was observed that the Bis-GMA based self-priming adhesive exhibited the least ARI scores, indicating a weak bonding with the enamel surface (Table/Fig 7) (19),(20),(23). Chang WG et al., and Bishara SE et al., reported that low ARI scores were beneficial in terms of reducing iatrogenic injury to the tooth during the debonding and polishing procedure (24),(25). According to an In-vitro investigation by Ramsundar K et al., there was no significant difference in bracket failures between primer-based and no primer-based adhesives (20).

In the current study, no significant difference in SBS was observed between the Bis-GMA containing primer-based adhesive (Transbond XT) and the HEMA-containing self-priming adhesive (Aqualine LC), and both materials exhibited good strength, indicating high clinical success. Various other studies have also reported good bracket survival when using the Bis-GMA containing primer-based adhesive (Transbond XT) (9),(26),(27). The present study observed the highest SBS with the HEMA-based self-priming adhesive (Aqualine LC), and comparable ARI scores were noted for both the HEMA-based self-priming adhesive (Aqualine LC) and the Bis-GMA containing primer-based adhesive (Transbond XT). These two adhesives can be recommended for clinical use.

Limitation(s)

The major limitation of present study is the In-vitro assessment. Further clinical studies should be conducted to evaluate the bracket failure rate of the adhesives under clinical conditions.

Conclusion

The Bis-GMA based self-priming adhesive (Orthofix SPA) exhibited lower SBS compared to the HEMA-based self-priming adhesive (Aqualine LC) and the Bis-GMA containing primer-based adhesive (Transbond XT). Additionally, the Bis-GMA based self-priming adhesive had very low ARI scores. Among the adhesives studied, the HEMA-based self-priming adhesive (Aqualine LC) showed the highest SBS. The ARI scores of the HEMA-based self-priming adhesive (Aqualine LC) and the Bis-GMA containing primer-based adhesive (Transbond XT) did not differ significantly.

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DOI and Others

DOI: 10.7860/JCDR/2023/65619.18723

Date of Submission: May 26, 2023
Date of Peer Review: Jul 17, 2023
Date of Acceptance: Sep 19, 2023
Date of Publishing: Nov 01, 2023

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. No

PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: May 26, 2023
• Manual Googling: Aug 18, 2023
• iThenticate Software: Sep 15, 2023 (14%)

ETYMOLOGY: Author Origin

EMENDATIONS: 7

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